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Traditionally, pharmaceutical wet granulation was based on batch processing techniques utilizing fluidization in the case of fluid bed granulator or mechanical agitation in high/low shear ...

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3.2 High-shear mixer All granulation experiments were carried out in a high-shear mixer DIOSNA P1-6 (Diosna, Dierks und Söhne , Osnabrück, Germany). A 4 L bowl with an impeller and chopper was used. The binder was added as a melt manually within 120 seconds using a syringe. The amount of powder bed was set to 800 g. Fig. 1: Experimental ...

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Rapid mixer granulator working principle - Pharma Manual. Mixing Chambers in Rapid mixer granulator is of 3 types Conical shaped Domed shape and Circular shaped although the basic aim behind all the shapes is to eliminate the dead points and wall adhesion i.e.the powder may not adhere to wall from where it cannot detach leading to inefficient granulation as well as mixing ..

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